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in disc assays
Electrical field stimulation-induced contraction of guinea pig superfused isolated tracheal preparations is significantly inhibited by Ensifentrine (10 μM)
whereas other transformed and normal human cells are several orders of magnitude less sensitive
15(22)23)6-11(19)14(12)21/h1-5
PG01 Catalog No.:M16477-C in disc assaysPG01 is a potent CFTR Cl channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0. 22 M, 0. 45 M and 1. 94 M, respectively. PG01 is also effective on F508 (Ka of 0. 3 M). PG01 increases F508 CFTR Cl current after adding Forskolin. Product information CAS Number: 853138 65 5 Molecular Weight: 439. 55 Formula: C28H29N3O2 Chemical Name: 2 [2 (1H indol 3 yl) N
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