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JZL195 is a potent and selective dual inhibitor of FAAH and monacylglycerol lipase (MAGL)
In vivo experiments using the KM12-bearing mouse xenograft model shows that DS-6051b induced tumor shrinkage at a ≥50 mg/kg or higher treatment dose without significant body weight loss
InChi: InChI=1S/C23H30N3O4S2
suggesting the involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency
PF-3644022 Catalog No.:M12254-2 JZL195 is a potent andPF 3644022 is a potent, selective, orally active and ATP competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5. 2 nM and a Ki of 3 nM. PF 3644022 also inhibits MK3 and p38 regulated activated kinase (PRAK) with IC50s of 53 nM and 5. 0 nM, respectively. PF 3644022 potently inhibits TNF production and has anti inflammatory effect. Product information CAS Number: 1276121 88 0 Molecular Weight: 374. 46 Formula: C21H18N4OS Chemical Name: (15R) 15 methyl 5
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