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Cidofovir is a Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor that is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis in people with AIDS
formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated
9)10)15(11
Akt2 and Akt3 with IC50 of 5 nM
CAL-130 - CAS# 1431697-74-3 Catalog No.:M9912-10 Cidofovir is a Cytomegalovirus NucleosideCAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support