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SR 1824 Catalog No.:M22508-C Formula: C34H32MnN4O4

SKU: 13405538748

4.4
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Description

Formula: C34H32MnN4O4

Receptor occupation and pharmacokinetics of MPC-1304

4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid calcium

Smiles: OCC1C=C(O)C2=C(C=1)C(=O)C1C=CC=C(O)C=1C2=O

SR 1824 Catalog No.:M22508-C Formula: C34H32MnN4O4Ki = 10 nM SR 1824 is a non agonist PPAR ligand. Peroxisome proliferator activated receptor (PPAR) can be activated by the anti diabetes drugs known as thiazolidinediones, including rosiglitazone and pioglitazone. Phosphorylation of PPAR by cyclin dependent kinase 5 (Cdk5) leads to dysregulation of genes whose expression is altered in obesity, such as adiponectin. In vitro: In a previous study, SR1824 was characterized for its ability to block Cdk5

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